Computational and systems biology of cancer
نویسندگان
چکیده
منابع مشابه
Bioinformatics and Computational Systems Biology of Cancer
Four decades of cancer molecular biology research have led to the identification of many molecular determinants of this pathology, and showed that they are organized in pathways which in turn are tightly interconnected in a complex network of interactions which covers essential cell processes (proliferation, death, differentiation, DNA repair, immune response...). The existence of crosstalks, f...
متن کاملReview of Computational Systems Biology of Cancer
* Correspondence: [email protected] Department of Electrical Engineering and Computer Science (Montefiore Institute) and GIGA (Interdisciplinary Cluster for Applied Geno-proteomics), Université de Liège, Liege, Belgium Book details Computational Systems Biology of Cancer by Emmanuel Barillot, Laurence Calzone, Philippe Hupé, Jean-Philippe Vert and Andrei Zinovyev. Chapman & Hall...
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Brain metastases occur in 20-40% of patients with advanced malignancies. A better understanding of the mechanism of this disease will help us to identify novel therapeutic strategies. In this review, we will discuss the systems biology approaches used in this area, including bioinformatics and mathematical modeling. Bioinformatics has been used for identifying the molecular mechanisms driving b...
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In recent years it has become clear that carcinogenesis is a complex process, both at the molecular and cellular levels. Understanding the origins, growth and spread of cancer, therefore requires an integrated or system-wide approach. Computational systems biology is an emerging sub-discipline in systems biology that utilizes the wealth of data from genomic, proteomic and metabolomic studies to...
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The complex biological systems consist of distinct molecules that exert their functions by interacting with each other, which makes it a big challenge to understand how the cellular machinery works. Recently, the accumulation of a large amount of multiscale omics data, such as nextgeneration sequencing data and protein interaction data, provides opportunity to investigate the functions of molec...
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ژورنال
عنوان ژورنال: Computational and Systems Oncology
سال: 2020
ISSN: 2689-9655,2689-9655
DOI: 10.1002/cso2.1005